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Title: Chemical composition and pharmacological activities of essential oils of Lavandula spp.
Authors: Martins, M. Rosário
Arantes, Silvia
Candeias, Fátima
Pereira, Marizia
Cruz-Morais, Júlio
Editors: Figueiredo, A. C.
Barroso, J. C.
Pedro, L.P
Keywords: Lavandula stoechas L. subsps. luisieri
Lavandula viridis L’Hér
essential oil composition
pharmacological activity
Issue Date: Sep-2012
Publisher: Centro de Biotecnologia Vegetal - Fundação da Faculdade de Ciências de Lisboa
Citation: Martins M R, Arantes S, Candeias M F, Pereira M, Cruz-Morais J (2012). Chemical composition and pharmacological activities of essential oils of Lavandula spp.. Proceedings of 43rd International Symposium on Essential Oils (ISEO2012), Faculdade de Ciências, Universidade de Lisboa, pp. 157. ISBN: 978-989-20-3188-0
Abstract: Lavandula spp. belong to the family Lamiatae and some species are often used in popular medicine and have been used for centuries in a large number of medical applications and in aromatherapy. Although similar ethnobotanical properties of Lavandula spp., its essential oils, general chemical composition and therapeutic applications differ from different species. Lavandula stoechas L. subsps. luisieri (Rozeira) Rozeira and L. viridis L’Hér are endemic to the Iberian Peninsula, widespread in the South of Portugal, namely in Southern Alentejo and Algarve. The aim of our study was evaluate the chemical composition and toxicological and pharmacological activities of leaves essential oils of spontaneous plants of L. stoechas L. subsps. luisieri (Alentejo) and L. viridis (Algarve). The essential oils of these wild plants, collected in spring, were obtained by hydrodistillation in a Clevenger-type apparatus and its chemical composition was evaluated by GC/FID. The acute toxicity of essential oils was evaluated "in vitro" using brine shrimp (LC50) and "in vivo" using Swiss mice (DL50). The analgesic and anti-inflammatory pharmacological properties of L. stoechas subsp. luisieri essential oil were evaluated in mouse or rats by the Amour-Smith and carrageen-induced paw edema tests, respectively. Results showed important differences in chemical composition of essential oils from two species analyzed either to diversity and proportion of its constituents. The essentials oils showed citotoxicity against Artemia salina and a DL50 higher than 2000 mg/kg for mice. The analgesic and anti-inflammatory activities of essential oils were exhibit for the doses of 100 and 200 mg/kg.
ISBN: 978-989-20-3188-0
Type: article
Appears in Collections:PAO - Artigos em Livros de Actas/Proceedings
QUI - Artigos em Livros de Actas/Proceedings
MED - Artigos em Livros de Actas/Proceedings

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