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Title: Ethyl 2,2-bis(4-methylphenylsulfonamido)acetate to aromatic alpha-amino acids: stable substrates for catalytic arylation reactions
Authors: Burke, Anthony
Marques, Carolina
Editors: Ghosez, Leon
Keywords: Síntese
Issue Date: 25-Nov-2013
Abstract: This paper reports the development of a novel methodology for the catalytic synthesis of aromatic alpha-amino acids, which involves the addition of aryl-organoboron reagents to alpha,alpha-ditosylamino esters derived from ethyl glyoxylate, using transition metal catalysts, like Rh and Pd. A library of alpha-amino esters (12 with Pd and 8 with Rh), was synthesized with moderate to excellent yields. A highest enantioselectivity of 30% ee was obtained using Hayashi's ligand. This method was applied to the synthesis of phenylglycine.
ISSN: 0040-4020
Type: article
Appears in Collections:QUI - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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