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Title: Asymmetric Catalytic Synthesis of -Aryl--Hydroxy Esters with Chiral Rhodium-NHC type Catalysts
Authors: Burke, Anthony
Marques, Carolina
Editors: Davies, Stephen
Keywords: Síntese
Issue Date: 15-Jun-2013
Abstract: Herein we describe for the first time the enantioselective catalytic arylation of ethyl glyoxalate using phenylboron reagents and chiral rhodium(I)-NHC catalysts. (KOBu)-Bu-t was the base of choice, along with tert-amyl alcohol as the solvent. A novel chiral bis-imidazolium salt was synthesized and evaluated for the first time in this catalytic transformation. Although moderate enantioselectivities (up to 34% ee) were obtained for the phenylation reaction, despite the excellent yields, very low enantioselectivities were obtained using other arylboronic acids with a variety of chiral rhodium(I)-NHC catalysts.
ISSN: 0957-4166
Type: article
Appears in Collections:QUI - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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