Please use this identifier to cite or link to this item:

Title: Evaluation of Phosphinoamidoester-Derived Pd Catalysts in the Asymmetric Allylic Alkylation Reaction: Theoretical Studies and Mechanistic Insights
Authors: Burke, Anthony
Ramalho, João Paulo
Marinho, Vanda
Editors: Berova, Nina
Caldwell, John
Issue Date: 1-May-2011
Publisher: Wiley-Blackwell
Abstract: Two simple hemilabile P,O-coordinating phosphinoamidoester ligands 6a and 6b were synthesized and studied in the Pd(0)-catalyzed asymmetric allylic alkylation of rac-1,3-diphenylpropenyl acetate affording a highest ee of 83% ee with 6a. To gain an insight into the actual mechanism of this catalytic reactions, which had previously been investigated with a first generation family of P,O-coordinating phosphinoamido-alcohol ligands-4a and 4b-a semiempirical computational study was carried out with the Pd-allyl complexes formed from both 4a and 6a including Hitchcock's phosphinoamido- alcohol ligand 5 (R(1) = 5 H, R(2) = 5 Ph). The results of this study substantiate a working model that has previously been proposed for this reaction using hemilabile P,O-coordinating phosphinoamido- type ligands. Chirality 23:383-388, 2011. (c) 2011 Wiley-Liss, Inc.
ISSN: 0899-0042
Type: article
Appears in Collections:CQE - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

Files in This Item:

File Description SizeFormat
Chirality paper Burke.pdf224.8 kBAdobe PDFView/OpenRestrict Access. You can Request a copy!
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Dspace Dspace
DSpace Software, version 1.6.2 Copyright © 2002-2008 MIT and Hewlett-Packard - Feedback
UEvora B-On Curriculum DeGois