Please use this identifier to cite or link to this item: http://hdl.handle.net/10174/36520

Title: Relationship between flame retardants and respiratory health– A systematic review and meta-analysis of observational studies
Authors: Coelho, Sonia Dias
Maricoto, Tiago
Taborda-Barata, Luís
Annesi-Maesano, Isabella
Isobe, Tomohiko
Sousa, Ana Catarina A
Keywords: Flame retardants
Rhinoconjunctivitis
PBDEs
Asthma
COPD
Rhinitis
Organophosphorus flame retardants
Respiratory diseases
Issue Date: 6-Mar-2024
Publisher: Elsevier
Citation: Coelho SD, Maricoto T, Taborda-Barata L, Annesi-Maesano I, Isobe T and Sousa ACA (2024). Relationship between flame retardants and respiratory health– A systematic review and meta-analysis of observational studies. Environmental Pollution 347: 123733. https://doi.org/10.1016/j.envpol.2024.123733
Abstract: Chronic respiratory diseases are a dealing cause of death and disability worldwide. Their prevalence is steadily increasing and the exposure to environmental contaminants, including Flame Retardants (FRs), is being considered as a possible risk factor. Despite the widespread and continuous exposure to FRs, the role of these contaminants in chronic respiratory diseases is yet not clear. This study aims to systematically review the association between the exposure to FRs and chronic respiratory diseases. Searches were performed using the Cochrane Library, MEDLINE, EMBASE, PUBMED, SCOPUS, ISI Web of Science (Science and Social Science Index), WHO Global Health Library and CINAHL EBSCO. Among the initial 353 articles found, only 9 fulfilled the inclusion criteria and were included. No statistically significant increase in the risk for chronic respiratory diseases with exposure to FRs was found and therefore there is not enough evidence to support that FRs pose a significantly higher risk for the development or worsening of respiratory diseases. However, a non-significant trend for potential hazard was found for asthma and rhinitis/rhinoconjunctivitis, particularly considering urinary organophosphate esters (OPEs) including TNBP, TPHP, TCEP and TCIPP congeners/compounds. Most studies showed a predominance of moderate risk of bias, therefore the global strength of the evidence is low. The limitations of the studies here reviewed, and the potential hazardous effects herein identified highlights the need for good quality large-scale cohort studies in which biomarkers of exposure should be quantified in biological samples.
URI: https://www.sciencedirect.com/science/article/pii/S0269749124004470?via%3Dihub
http://hdl.handle.net/10174/36520
Type: article
Appears in Collections:CHRC - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
BIO - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

Files in This Item:

File Description SizeFormat
Coelho et al EnvPol 2024.pdf5.06 MBAdobe PDFView/Open
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Dspace Dspace
DSpace Software, version 1.6.2 Copyright © 2002-2008 MIT and Hewlett-Packard - Feedback
UEvora B-On Curriculum DeGois