Please use this identifier to cite or link to this item:

Title: From Plant Survival Under Severe Stress to Anti-Viral Human Defense - A Perspective That Calls for Common Efforts
Authors: Arnholdt-Schmitt, Birgit
Mohanapriya, Gunasekaran
Bharadwaj, Revuru
Noceda, Carlos
Macedo, Elisete Santos
Sathishkumar, Ramalingam
Gupta, Kapuganti Jagadis
Sircar, Debabrata
Kumar, Sarma Rajeev
Srivastava, Shivani
Alok, Adholeya
Thiers, Karine Leitão Lima
Aziz, Shahid
Velada, Isabel
Oliveira, Manuela
Quaresma, Paulo
Achra, Arvind
Gupta, Nidhi
Kumar, Ashwani
Costa, José Hélio
Editors: Kozlakidis, Zisis
Keywords: viral diseases
early cell reprogramming
somatic embryogenesis
alternative oxidase (AOX)
aerobic fermentation
stress tolerance
Issue Date: 15-Jun-2021
Publisher: Frontiers Media
Citation: Arnholdt-Schmitt B, Mohanapriya G, Bharadwaj R, Noceda C, Macedo ES, Sathishkumar R, Gupta KJ, Sircar D, Kumar SR, Srivastava S, Adholeya A, Thiers KL, Aziz S, Velada I, Oliveira M, Quaresma P, Achra A, Gupta N, Kumar A and Costa JH (2021) From Plant Survival Under Severe Stress to Anti-Viral Human Defense – A Perspective That Calls for Common Efforts. Front. Immunol. 12:673723. doi: 10.3389/fimmu.2021.673723
Abstract: Reprogramming of primary virus-infected cells is the critical step that turns viral attacks harmful to humans by initiating super-spreading at cell, organism and population levels. To develop early anti-viral therapies and proactive administration, it is important to understand the very first steps of this process. Plant somatic embryogenesis (SE) is the earliest and most studied model for de novo programming upon severe stress that, in contrast to virus attacks, promotes individual cell and organism survival. We argued that transcript level profiles of target genes established from in vitro SE induction as reference compared to virus-induced profiles can identify differential virus traits that link to harmful reprogramming. To validate this hypothesis, we selected a standard set of genes named ‘ReprogVirus’. This approach was recently applied and published. It resulted in identifying ‘CoV-MAC-TED’, a complex trait that is promising to support combating SARS-CoV-2-induced cell reprogramming in primary infected nose and mouth cells. In this perspective, we aim to explain the rationale of our scientific approach. We are highlighting relevant background knowledge on SE, emphasize the role of alternative oxidase in plant reprogramming and resilience as a learning tool for designing human virus-defense strategies and, present the list of selected genes. As an outlook, we announce wider data collection in a ‘ReprogVirus Platform’ to support anti-viral strategy design through common efforts.
Type: article
Appears in Collections:CIMA - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

Files in This Item:

File Description SizeFormat
fimmu-12-673723.pdf595.12 kBAdobe PDFView/Open
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Dspace Dspace
DSpace Software, version 1.6.2 Copyright © 2002-2008 MIT and Hewlett-Packard - Feedback
UEvora B-On Curriculum DeGois