Please use this identifier to cite or link to this item:

Title: Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity
Authors: Brandão, Pedro
Marques, Carolina S.
Carreiro, Elisabete P.
Pineiro, Marta
Burke, Anthony J.
Keywords: isatin
multicomponent reactions
Issue Date: 14-Feb-2021
Publisher: The Chemical Society of Japan & Wiley-VCH GmbH
Abstract: Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry. Isatin, due to its unique reactivity, can undergo different MCRs, affording multiple interesting scaffolds, namely oxindole-derivatives (including spirooxindoles, bis-oxindoles and 3,3-disubstituted oxindoles) and even, under certain conditions, ring-opening reactions occur that leads to other heterocyclic compounds. Over the past few years, new methodologies have been described for the application of this important and easily available starting material in MCRs. In this review, we explore these novelties, displaying them according to the structure of the final products obtained.
Type: article
Appears in Collections:LAVQ-REQUIMTE - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

Files in This Item:

File Description SizeFormat
The Chemical Record 2021.pdf28.68 MBAdobe PDFView/Open
FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpaceOrkut
Formato BibTex mendeley Endnote Logotipo do DeGóis 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


Dspace Dspace
DSpace Software, version 1.6.2 Copyright © 2002-2008 MIT and Hewlett-Packard - Feedback
UEvora B-On Curriculum DeGois