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Title: Magnetite nanoparticles functionalized with propolis against methicillin resistant strains of Staphylococcus aureus
Authors: El-Guendouz, Soukaina
Lyoussi, Badiaa
Lourenço, João P.
Rosa da Costa, Ana M.
Miguel, Maria G.
Barrocas Dias, Cristina
Manhita, Ana
Jordão, Luísa
Nogueira, Isabel
Faleiro, Maria L.
Keywords: Pyrolysis GC/MS
Antibacterial activity
Propolis extract / magnetite nanoparticles
Issue Date: 2019
Publisher: Elsevier
Citation: Soukaina El-Guendouz, Badiaa Lyoussi, João P. Lourenço, Ana M. Rosa da Costa, Maria G. Miguel, Cristina Barrocas Dias, Ana Manhita, Luisa Jordao, Isabel Nogueira, Maria L. Faleiro, Magnetite nanoparticles functionalized with propolis against methicillin resistant strains of Staphylococcus aureus, Journal of the Taiwan Institute of Chemical Engineers, Volume 102, 2019, Pages 25-33
Abstract: Magnetite nanoparticles (MNPs) have been evaluated for inhibiting microbial growth and biofilm formation. In this study the effect of the nanocomposite Moroccan propolis extract / MNPs acting against methicillin resistant strains of Staphylococcus aureus (MRSA) was evaluated. Chemical composition of propolis was established by pyrolysis coupled to gas chromatography and mass spectrometry method (pyrolysis GC/MS). MNPs were obtained through the co-precipitation method. The fabricated nanostructure was characterized by X-ray Diffraction (DRX), Transmission Electron Microscopy (TEM), and Fourier Transform-Infrared Spectroscopy (FTIR). TEM of MNPs provided a particle average size of 15 nm, FTIR spectral analysis enabled a fast way of identification of MNPs, attesting the occurrence of the different combinations. The use of MNPs loaded with propolis and the antibiotic chloramphenicol at Minimum Inhibitory Concentration (MIC) value inhibited the bacterial growth of MSSA (methicillin susceptible strain of S. aureus) and MRSA strains. After the treatment with MNPs-OA-P-CLo nanocomposite (MNPs with oleic acid, propolis and chloramphenicol), the disruption of the bacterial cell was observed by TEM. The combination of propolis and chloramphenicol in free form at MIC value largely impaired both MSSA and MRSA strains as, after 2 h of treatment, no viable cells of MRSA 2 and MRSA 16 were recovered. Hence, the results elucidated a new antibacterial nanocomposite synthesis, for possible applications as prospective nanoantibacterial agents or drug carriers.
Type: article
Appears in Collections:HERCULES - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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