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Title: Structure of a dioxygen reduction enzyme from Desulfovibrio gigas
Authors: Frazão, Carlos
Silva, Gabriela
Gomes, Claudio
Matias, Pedro
Coelho, R
Sieker, L
Macedo, S
Liu, MY
Oliveira, Solange
Teixeira, Miguel
Xavier, António V.
Rodrigues-Pousada, Claudina
Carrondo, M. Arménia
LeGall, Jean
Keywords: ROO
Desulfovibrio gigas
Issue Date: 2000
Abstract: Desulfovibrio gigas is a strict anaerobe that contains a well-characterized metabolic pathway that enables it to survive transient contacts with oxygen. The terminal enzyme in this pathway, rubredoxin:oxygen oxidoreductase (ROO) reduces oxygen to water in a direct and safe way. The 2.5 Angstrom resolution crystal structure of ROO shows that each monomer of this homodimeric enzyme consists of a novel combination of two domains, a flavodoxin-like domain and a Zn-beta -lactamase-like domain that contains a di-iron center for dioxygen reduction. This is the first structure of a member of a superfamily of enzymes widespread in strict and facultative anaerobes, indicating its broad physiological significance.
Type: article
Appears in Collections:MED - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
BIO - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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