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|Title: ||Pharmacological and Toxicological Studies of Essential Oil of Lavandula stoechas subsp. luisieri.|
|Authors: ||Arantes, Sílvia|
Martins, M. Rosário
|Keywords: ||Lavandula luisieri|
|Issue Date: ||28-Apr-2016|
|Publisher: ||Georg Thieme Verlag KC|
|Citation: ||- Sílvia Arantes, Fátima Candeias, Orlando Lopes, Mónica Lima, Marízia Pereira, Teresa Tinoco, J. Cruz-Morais, M. Rosário Martins. (2016). Pharmacological and Toxicological Studies of Essential Oil of Lavandula stoechas subsp. luisieri. Planta Medica, 82: 1266-1273. DOI 10.1055/s-0042-104418.|
|Abstract: ||The present study was carried out to evaluate the chemical and pharmacological properties of essential oil (EO) of Lavandula stoechas L. subsp. luisieri that is a spontaneous shrub widespread in Alentejo (Portugal). Oxygenated monoterpenes, as 1,8-cineole, lavandulol and necrodane derivatives are the main components of essential oil. It revealed important antioxidant activity with high ability to inhibit the lipid peroxidation and showed an outstanding effect against a wide spectrum of microorganisms, such as Gram-positive and Gram-negative bacteria and pathogenic yeasts. The analgesic effect studied in rats was dose dependent, reaching a maximum of 67 % at 60 min. with the dose of 200 mg/kg and the anti-inflammatory activity with this dose caused an inhibition in carrageenan-induced rat paw oedema (83 %) that is higher than dexamethasone 1 mg/Kg (69 %). Besides, animals exhibited a normal behaviour after EO administration revealing low toxicity.
Essential oil of L. luisieri from Alentejo that presents important pharmacological properties and low toxicity is a promised candidate to be used as food supplement or in pharmaceutical applications.|
|Appears in Collections:||MED - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica|
QUI - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
BIO - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
HERCULES - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
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