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|Title: ||Characterization of hypertrophic osteoarthropathy in an identified skeleton from Évora, Portugal, using combined and comparative morphology and microscopy|
|Authors: ||Anselmo, Daniela|
Capela e Silva, F
|Keywords: ||Hypertrophic osteoarthropathy|
Scanning electron microscopy
|Issue Date: ||2016|
|Citation: ||Anselmo D, Capela e Silva F, Fernandes T. Characterization of Hypertrophic Osteoarthropathy in an identified skeleton from Évora, Portugal, using combined and comparative morphology and microscopy. International Journal of Paleopathology 2016; 12:11-6.|
|Abstract: ||Hypertrophic osteoarthropathy (HOA) is a bone pathology that can be associated with a number of focal
or systemic diseases, particularly those affecting the respiratory system. HOA is characterized by proliferative
periostosis of the long bones, especially in their distal and periarticular regions. This report
presents a probable case of HOA in the skeleton of an elderly Portuguese male from Évora, Portugal, who
died in 1970.
The skeleton was evaluated by morphological, radiological, and histological methods. We found bilateral
periosteal proliferation of the tubular bones, remodeling of the phalanges of the feet, and new bone
formation on rib visceral surfaces. Bone alterations are more severe on the left tibia and fibula, where
lesions display a ‘tree bark’ appearance, leading to severe thickening of the diaphysis.
Microscopically, we observed deposition of porous woven bone. Our evaluation also considers a differential
diagnosis of the lesions, which includes melorheostosis, hypervitaminosis A, fluorosis, thyroid
acropachy, tuberculosis, and treponematosis.|
|Appears in Collections:||MED - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica|
BIO - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
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