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|Title: ||Determinants of the Sympatric Host-Pathogen Relationship in Tuberculosis|
|Authors: ||David, Susana|
Mateus, A. R. A.
Duarte, Elsa L.
|Issue Date: ||2015|
|Citation: ||David, Susana; Mateus, A. R. A.; Duarte, Elsa L.; Albuquerque, José; Portugal, Clara; Sancho, Luísa; Lavinha, João; Gonçalves, Guilherme. Determinants of the Sympatric Host-Pathogen Relationship in Tuberculosis, PLOS ONE, 10, 11, e0140625-e0140625, 2015.|
|Abstract: ||Major contributions from pathogen genome analysis and host genetics have equated the
possibility of Mycobacterium tuberculosis co-evolution with its human host leading to more
stable sympatric host–pathogen relationships. However, the attribution to either sympatric
or allopatric categories depends on the resolution or grain of genotypic characterization.
We explored the influence on the sympatric host-pathogen relationship of clinical (HIV
infection and multidrug-resistant tuberculosis [MDRTB]) and demographic (gender and
age) factors in regards to the genotypic grain by using spacer oligonucleotide typing (spoligotyping)
for classification of M. tuberculosis strains within the Euro-American lineage. We
analyzed a total of 547 tuberculosis (TB) cases, from six year consecutive sampling in a
setting with high TB-HIV coinfection (32.0%). Of these, 62.0% were caused by major circulating
pathogen genotypes. The sympatric relationship was defined according to spoligotype
in comparison to the international spoligotype database SpolDB4. While no significant
association with Euro-American lineage was observed with any of the factors analyzed,
increasing the resolution with spoligotyping evidenced a significant association of MDRTB
with sympatric strains, regardless of the HIV status. Furthermore, distribution curves of the
prevalence of sympatric and allopatric TB in relation to patients’ age showed an accentuation
of the relevance of the age of onset in the allopatric relationship, as reflected in the trimodal
distribution. On the contrary, sympatric TB was characterized by the tendency
towards a typical (standard) distribution curve. Our results suggest that within the Euro-
American lineage a greater degree of genotyping fine-tuning is necessary in modeling the
biological processes behind the host-pathogen interplay. Furthermore, prevalence distribution
of sympatric TB to age was suggestive of host genetic determinisms driven by more
|Other Identifiers: ||1932-6203|
|Appears in Collections:||MVT - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica|
MED - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
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