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Title: The role of acetylcholinesterase in Alzheimer’s disease: Enzymatic inhibition studies
Authors: Bacalhau, P.
Marques, C.
Martins, M.R.
Caldeira, A.T.
Burke, A.
Editors: Oliveira, P.
Ambrósio F., F.
Vega-Naredo, I.
Laranjinha, J.
Oliveira, T.
Serafim, T.
Sardão, V.
Keywords: Alzheimer’s disease
reversible inhibitors
quinolinone derivatives
indole derivatives
Issue Date: Dec-2014
Publisher: CNCB UC Editions
Citation: Bacalhau P., Marques C., Martins M. R., Caldeira A.T., Burke A. J. (2014) The role of acetylcholinesterase in Alzheimer’s disease: enzymatic inhibition studies. Proceedings of the XVIII Congress of the Portuguese Biochemical Society, (Oliveira P., Ambrósio F., Vega-Naredo I., Laranjinha J., Oliveira T., Serafim T., Sardão V. Eds) CNCBUC Editions, Coimbra, pp.73
Abstract: Alzheimer’s disease (AD) is the most common form of dementia and causes a progressive and irreversible neurodegeneration. It is related with loss of cholinergic function, which affects memory, learning and behavior [1]. Neurophathologically, AD is characterized by the presence of beta-amyloid plaques (A ) and neurofibrillary tangles (NFT) [2] and consequent degeneration of the basal forebrain cholinergic neurons [3]. The loss of cholinergic neurons leads to the progressive reduction of acetylcholine (ACh) in the brain and resulting cognitive impairment in AD [3]. As such, the enzyme acetylcholinesterase (AChE) has been one of the prime targets in search for a treatment for AD, which uses reversible inhibitors of AChE, in order to increase levels of acetylcholine (ACh) in the brain [4]. In the present study a small library of quinolinone and indole derivatives was screened for their eeAChE inhibitory activity using the Ellman method.
Type: article
Appears in Collections:CQE - Artigos em Livros de Actas/Proceedings
MED - Artigos em Livros de Actas/Proceedings

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