Please use this identifier to cite or link to this item: http://hdl.handle.net/10174/5733

Title: Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation.
Authors: Frias, C
Reis, J
Capela e Silva, F
Potes, J
Simões, J
Marques, AT
Keywords: Polymeric piezoelectric
Actuator
Osteoblast cells
Mechanical stimulation
Issue Date: 2010
Publisher: Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation.
Citation: Frias C, Reis J, Capela e Silva F, Potes J, Simões J, Marques AT. Polymeric piezoelectric actuator substrate for osteoblast mechanical stimulation. J Biomechanics 2010; 43: 1061-1066.
Abstract: Bone mass distribution and structure are dependent on mechanical stress and adaptive response at cellular and tissue levels. Mechanical stimulation of bone induces new bone formation in vivo and increases the metabolic activity and gene expression of osteoblasts in culture. A wide variety of devices have been tested for mechanical stimulation of cells and tissues in vitro. The aim of this work was to experimentally validate the possibility to use piezoelectric materials as a mean of mechanical stimulation of bone cells, by converse piezoelectric effect. To estimate the magnitude and the distribution of strain, finite numerical models were applied and the results were complemented with the optical tests (Electronic Speckle Pattern Interferometric Process). In this work, osteoblasts were grown on the surface of a piezoelectric material, both in static and dynamic conditions at low frequencies, and total protein, cell viability and nitric oxide measurement comparisons are presented.
URI: http://hdl.handle.net/10174/5733
Type: article
Appears in Collections:ICAAM - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
BIO - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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