Please use this identifier to cite or link to this item: http://hdl.handle.net/10174/7008

Title: A new piezoelectric actuator induces bone formation in vivo: a preliminary study
Authors: Reis, J
Frias, C
Canto e Castro, C
Botelho, ML
Marques, AT
Simões JA, JA
Capela e Silva, F
Potes, J
Keywords: Bone
osteoblasts
Piezoelectric Actuator
sheep
Issue Date: 2012
Publisher: Hindawi Publishing Corporation
Citation: Reis J, Frias C, Canto e Castro C, Botelho ML, Marques AT, Simões JA, Capela e Silva F, Potes J. A new piezoelectric actuator induces bone formation in vivo: a preliminary study. Journal of Biomedicine and Biotechnology 2012; Article ID 613403, doi:10.1155/2012/613403
Abstract: This in vivo study presents the preliminary results of the use of a novel piezoelectric actuator for orthopedic application. The innovative use of the converse piezoelectric effect to mechanically stimulate bone was achieved with polyvinylidene fluoride actuators implanted in osteotomy cuts in sheep femur and tibia. The biological response around the osteotomies was assessed through histology and histomorphometry in nondecalcified sections and histochemistry and immunohistochemistry in decalcified sections, namely, throughMasson’s trichrome, and labeling of osteopontin, proliferating cell nuclear antigen, and tartrate-resistant acid phosphatase. After one-month implantation, total bone area and new bone area were significantly higher around actuators when compared to static controls. Bone deposition rate was also significantly higher in the mechanically stimulated areas. In these areas, osteopontin increased expression was observed. The present in vivo study suggests that piezoelectric materials and the converse piezoelectric effect may be used to effectively stimulate bone growth.
URI: http://hdl.handle.net/10174/7008
Type: article
Appears in Collections:ICAAM - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
BIO - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
MVT - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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