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|Title: ||Expressão da caderina na discondroplasia tibial|
|Authors: ||Capela e Silva, F|
|Keywords: ||discondroplasia da tibia|
|Issue Date: ||2010|
|Citation: ||Capela e Silva F, Lamy E, Pereira A, Reis J, Potes J, Cabrita AS. Expressão da caderina na discondroplasia tibial. Arq Bras Med Vet Zootec 2010; 62: 214-218.|
|Abstract: ||By immunohistochemistry the expression of a pan-cadherin antibody that recognizes a wide variety of
cadherins in chondrocytes from normal and tibial dyschondroplasia (TD) growth plates was compared.
Surprisingly, an upregulated expression that was not expected in TD lesion chondrocytes was observed.
The reason for this apparent upregulation is not clear. The increased expression may simply be due to the
particular phenotype of lesion chondrocytes, and cadherin may be involved in apoptosis of chondrocytes
of TD lesion. Another possibility, is that a low level of calcium in the lesion may be responsible for the
observed upregulation. The results of the present study suggest that the formation of the
dyschondroplastic lesion is not merely due to the impaired terminal differentiation of lesion chondrocytes
and that other mechanisms are probably involved in TD etiology. Further studies will be necessary to
provide insight into the precise nature of the condition.|
|Appears in Collections:||MED - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica|
BIO - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
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