Please use this identifier to cite or link to this item: http://hdl.handle.net/10174/16940

Title: Effects of high fat diet on salivary alpha-amylase serum parameters and food consumption in rats
Authors: Rodrigues, L
Mouta, R
Costa, AR
Pereira, A
Capela e Silva, F
Amado, F
Antunes, CM
Lamy, E
Keywords: Weight gain
High-fat diet
Leptin
Rats
Salivary amylase
Issue Date: 2015
Publisher: ELSEVIER
Citation: Rodrigues L, Mouta R, Costa AR, Pereira A, Capela e Silva F, Amado F, Antunes CM, Lamy E. Effects of high fat diet on salivary a-amylase, serum parameters and food consumption in rats. Archives of Oral Biology 2015; 60: 854-62.
Abstract: Salivary a-amylase, a major protein in saliva, has been described as a marker for sympathetic nervous system activity, hence for metabolic energy balance. In this context, its expression in overweight and obesity is of interest. Rats fed with a diet enriched with sunflower oil differentially gained weight yielding two subgroups according to their susceptibility (OP) or resistance (OR) to obesity. Elevated plasmatic levels of leptin in the OP subgroup and altered plasmatic lipid profiles (lower triglycerides and higher total choles- terol/HDL ratio compared to controls) in OR subgroup were observed. Animals from OP subgroup presented higher a-amylase expression and activity even prior to the dietary treatment, suggesting that this salivary protein may constitute a putative indicator of susceptibility for fat tissue accumulation. After 18 weeks of high-fat diet consumption, salivary a-amylase levels did not significantly changed in OP subgroup, but increased 3-fold in OR subgroup. The raise of a-amylase for the latter might represent an adaptation to lower starch intake. These results suggest that salivary a-amylase secretion might be useful to predict susceptibility for weight gain induced by high-fat diet consumption.
URI: http://dx.doi.org/10.1016/j.archoralbio.2015.02.015
http://hdl.handle.net/10174/16940
Type: article
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