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Title: Novel 1-hydroxy-1,1-bisphosphonates derived from indazole: synthesis and characterization
Authors: Teixeira, Fátima C.
Antunes, Inês F.
Curto, M. João M.
Neves, M.
Teixeira, António P. S.
Keywords: Bisphosphonates
N-1 and N-2 isomers,
spectroscopic characterization
Issue Date: 2009
Publisher: Arkat USA, Inc
Abstract: Bisphosphonates (BPs) are an important class of drugs used in the treatment of abnormal calcium metabolism diseases. The first syntheses of bisphosphonates derived from indazole, substituted at the N-1, N-2 and C-3 positions are reported. The 1-hydroxy-1,1-bisphosphonates were synthesized from the corresponding carboxylic acid or acyl chloride compounds, by two different methods. These BPs have a side chain with different lengths ((CH2)n, n = 0-5) between the indazole ring and the bisphosphonate group.
ISSN: 1551-7012
Type: article
Appears in Collections:QUI - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
CQE - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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