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Title: Animal models of colorectal cancer: from spontaneous to genetically engineered models and their applications
Authors: Nascimento-Gonçalves, Elisabete
Mendes, Bruno
Silva-Reis, Rita
Faustino-Rocha, Ana Isabel
Gama, Adelina
Oliveira, Paula Alexandra
Keywords: spontaneous models
induced models
genetically engineered models
Issue Date: 2021
Publisher: Veterinary Sciences
Citation: Nascimento-Gonçalves E, Mendes BAL, Silva-Reis R, Faustino-Rocha AI, Gama A, Oliveira PA. 2021. Animal models of colorectal cancer: from spontaneous to genetically engineered models and their applications. Veterinary Sciences 8(4): 59.
Abstract: Colorectal cancer is one of the most common gastrointestinal malignancies in humans, affecting approximately 1.8 million people worldwide. This disease has a major social impact and high treatment costs. Animal models allow us to understand and follow the colon cancer progression; thus, in vivo studies are essential to improve and discover new ways of prevention and treatment. Dietary natural products have been under investigation for better and natural prevention, envisioning to show their potential. This manuscript intends to provide the readers a review of rodent colorectal cancer models available in the literature, highlighting their advantages and disadvantages, as well as their potential in the evaluation of several drugs and natural compounds’ effects on colorectal cancer.
Type: article
Appears in Collections:ZOO - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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