Please use this identifier to cite or link to this item: http://hdl.handle.net/10174/26006

Title: Microtomographic characterization of calcifications in canine mammary tumours
Authors: Reis, Joana
Oliveira, Teresa
Pereira, Alfredo
Leal, Nuno
Faísca, Pedro
Infante, Paulo
Editors: Comazzi, Stefano
Thamm, Douglas
Keywords: animal model
calcifications
canine mammary tumours
microcalcifications
microtomography
Issue Date: 12-Oct-2019
Publisher: Veterinary and Comparative Oncology - Wiley
Citation: doi: 10.1111/vco.12545
Abstract: The present work describes the microtomographic characterization of macro and microcalcifications present in excised canine mammary glands. In human breast cancer, microcalcifications are highly relevant for diagnosis and prognosis, often being the sole element determining biopsy. Canine mammary tumours are considered a model for human breast cancer, but the morphological features of calcifications had still to be studied in this species. The objective of this research is to contribute to the characterization of the mineralization features of the canine mammary gland. In the present study, the excised mammary glands of 33 bitches underwent fluoroscopic examination. In 30 of the samples, the presence of calcification was suspected, and multiple biopsies were taken of these areas. Biopsy fragments underwent microtomographic scanning. Microcalcifications were found in non-neoplastic glandular tissue, benign and malign lesions, as it is known to happen in humans. Qualitative evaluation regarding morphology of the imaged calcifications showed similarities to breast cancer findings, based on the BI-RADS 2013 classification, such as pleomorphism and shape. No differences in the quantitative morphological parameters of volume, surface, surface/volume, SMI and structure thickness were found when macrocalcifications were considered. However, although significant differences existed in these parameters between microcalcifications from malignant canine mammary tumours and the two other groups, none were found between non-neoplastic and benign tumours. Findings further support the use of this spontaneous animal model for the study of human breast cancer, considering how clinically relevant microcalcifications are in humans.
URI: https://onlinelibrary.wiley.com/doi/epdf/10.1111/vco.12545
http://hdl.handle.net/10174/26006
Type: article
Appears in Collections:MVT - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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