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|Title: ||Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodies|
|Authors: ||Trinca, Francisco|
|Keywords: ||breast neoplasm|
quality of life
|Issue Date: ||2019|
|Citation: ||Trinca, F., Infante, P. Dinis, R. Inácio, M., Bravo, E., Caravana, J., Reis, T. Marques, S. (2019). Depression and quality of life in patients with breast cancer undergoing chemotherapy and monoclonal antibodies, ecancer 13:937, p. 1-20.|
|Abstract: ||Background: Depression is one of the major psychiatric morbidities in cancer patients.
The purpose of our study was to evaluate the impact of depressive symptoms in the quality of life (QoL) of patients with breast cancer undergoing chemotherapy and monoclonal
Methods: Observational, cross-sectional study conducted between April and November
2016. To evaluate the QoL, the EORTC QLQ-C30 and QLQ-BR23 questionnaire were
used. The patients were screened for depressive symptoms using the Hospital Anxiety
and Depression Scale (HADS-D) and those with a positive HADS-D positive questionnaire were referenced to the Psychiatry and Mental Health Department for further
assessment and follow-up.
Results: We included 45 female patients. Sixteen (35.6%) patients had a positive HADSD questionnaire and depressive symptoms confirmed by a psychiatric physician. Of those
patients, 7 (15.6%) had a major depressive episode confirmed by psychiatric interview.
There was a significant association of depressive symptoms with the future perspectives
scale (p = 0.022), breast symptoms scale (p = 0.011) and arm symptom scale (p = 0.005).
Significant differences were found in the fatigue (p = 0.024), pain (p = 0.037) and dyspnea
(p = 0.009) subscales being worse in patients with depressive symptoms. The association
between having depressive symptoms or not was shown to be significant or marginally
significant for the variables stage of the tumour (p = 0.057), presence of distant metastasis (p = 0.072) and previous diagnosis of depression (p = 0.011). The patients treated with
regimens containing monoclonal antibodies presented better outcomes in various subscales of the EORTC QLQ-C30 and QLQ-B23 questionnaires than those patients treated
with chemotherapy regimens without monoclonal antibodies.
Conclusions: Despite the small sample of our study, this study provided evidence that
depressive symptoms in patients with breast cancer undergoing chemotherapy and
monoclonal antibodies treatments detrimentally reduced various aspects of QoL|
|Appears in Collections:||MAT - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica|
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