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Title: Frequency and functional activity of Th17, Tc17 and other T-cell subsets in Systemic Lupus Erythematosus
Authors: Henriques, Ana
Inês, Luís
Couto, Maura
Pedreiro, Susana
Santos, Catarina
Magalhães, Mariana
Santos, Paulo
Velada, Isabel
Almeida, Anabela
Carvalheiro, Tiago
Laranjeira, Paula
Morgado, José Mário
Pais, Maria Luísa
Silva, José António Pereira da
Paiva, Artur
Issue Date: 2010
Citation: Henriques, Ana; Inês, Luís; Couto, Maura; Pedreiro, Susana; Santos, Catarina; Magalhães, Mariana; Santos, Paulo; Velada, Isabel; Almeida, Anabela; Carvalheiro, Tiago; Laranjeira, Paula; Morgado, José Mário; Pais, Maria Luísa; Silva, José António Pereira da; Paiva, Artur. Frequency and functional activity of Th17, Tc17 and other T-cell subsets in Systemic Lupus Erythematosus, Cellular Immunology, 264, 1, 97-103, 2010.
Abstract: To compare frequency and functional activity of peripheral blood (PB) Th(c)17, Th(c)1 and Treg cells and the amount of type 2 cytokines mRNA we recruited SLE patients in active (n = 15) and inactive disease (n = 19) and healthy age- and gender-matched controls (n = 15). The study of Th(c)17, Th(c)1 and Treg cells was done by flow cytometry and cytokine mRNA by real-time PCR. Compared to NC, SLE patients present an increased proportion of Th(c)17 cells, but with lower amounts of IL-17 per cell and also a decreased frequency of Treg, but with increased production of TGF-b and FoxP3 mRNA. In active compared to inactive SLE, there is a marked decreased in frequency of Th(c)1 cells, an increased production of type 2 cytokines mRNA and a distinct functional profile of Th(c)17 cells. Our findings suggest a functional disequilibrium of T-cell subsets in SLE which may contribute to the inflammatory process and disease pathogenesis.
Other Identifiers: 00088749
Type: article
Appears in Collections:ICAAM - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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