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|Title: ||Anti-proliferative effects of novel hydroxyamides and triazoles|
|Authors: ||Martins, Tiago S.|
Pires, Tiago O.
Cordeiro, Maria M.
Antunes, Célia M.
Costa, Ana R.
|Editors: ||Taussig, Mike|
|Issue Date: ||2016|
|Citation: ||Tiago S. Martins, Tiago O. Pires, Maria M. Cordeiro, Rute Martins, Elisabete P. Carreiro, Luis Alves, Anthony Burke, Célia M. Antunes, Ana R. Costa (2016) "Anti-proliferative effects of novel hydroxyamides and triazoles", NEW BIOTECHNOLOGY 33(3), 416-417.|
|Abstract: ||Chemotherapy is a major cancer treatment option. The synthesis of new compounds with anti-proliferative properties and specificity is a current challenge in drug-discovery today. Our goal was to develop compounds, either hydroxyamides derived from D-glucuronic acid or triazole-cinchone hybrids, and to evaluate their anti-proliferative properties.
Anti-proliferative activity of the newly synthesized compounds was examined against human breast adenocarcinoma (MCF-7) and human colon carcinoma (MDST8) cell-lines. Cell growth and viability was analysed by the Cell-Counting Kit-8 method. The 5-fluoroacil was used as a positive control. The compounds were studied between 10-9-10-5M. Fifteen compounds from the hydroxyamide family and two triazole compounds were investigated.
Most of the compounds from the hydroxyamide family revealed mild (~20%) to moderate (50%) anti-proliferative effects in both cell-lines, with the exception of Hydroxyamide B1 which did not affect MDST8 proliferation, and hydroxyamide B3 where proliferation of MDST8 was inhibited by 90%. Triazoles (A and B) evoked a strong (~100%) anti-proliferative effect of MDST8 cell-lines. Proliferation of MCF-7 was selectively and effectively (~98%) inhibited by triazole B while triazole A had a mild effect.
In conclusion, when compared to hydroxyamides, triazoles evoked a stronger anti-proliferative effect and might be promising anti-tumoral drugs.|
|Appears in Collections:||ICT - Artigos em Livros de Actas/Proceedings|
ICAAM - Artigos em Livros de Actas/Proceedings
QUI - Artigos em Livros de Actas/Proceedings
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