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Title: Changes in the salivary protein profile of morbidly obese women either previously subjected to bariatric surgery or not
Authors: Lamy, Elsa
Simões, Carla
Rodrigues, Lénia
Rodrigues Costa, Ana
Vitorino, Rui
Amado, Francisco
Antunes, Célia
do Carmo, Isabel
Editors: Lostao, M.Pilar
Moreno-Aliaga, M.Jesús
Keywords: saliva
protein profile
Issue Date: Dec-2015
Publisher: Springer
Citation: Elsa Lamy, Carla Simões, Lénia Rodrigues, Ana Rodrigues Costa, Rui Vitorino, Francisco Amado, Célia Antunes, Isabel do Carmo “Changes in salivary protein profile in morbid obese women with and without bariatric surgery", Journal of Physiology and Biochemistry”, December 2015, Volume 71, Issue 4, pp 691-702.
Abstract: Saliva is a non-invasive source of biomarkers useful in the study of physiological mechanisms. Moreover, this fluid has diverse functions, among which food perception and ingestion, making it particularly suitable for the study of obesity. The aims of this study were to assess changes in salivary proteome among morbidly obese women, with a view to provide information about mechanisms potentially related to the development of obesity, and to evaluate whether these changes persist after weight loss. Mixed saliva samples from morbidly obese women (N = 18) who had been either subjected (group O-BS) or not (group O) to bariatric surgery and women with normal weight (N = 14; group C) were compared for protein profiles, alpha-amylase abundance and enzymatic activity, and carbonic anhydrase (CA) VI abundance. Differences in salivary obese profiles were observed for 23 different spots. Zinc-alpha-2 glycoprotein-containing spots showed higher abundance in group O only, whereas cystatin S-containing spots presented higher abundance in the two groups of obese subjects. Most of the spots identified as salivary amylase were present at lower levels in group O-BS. With regard to the amylase enzymatic activity, increases were observed for group O and decreases for group O-BS. One interesting finding was the high correlation between levels of CA VI and body mass index in group O, which was not observed for groups O-BS or C. The differences between groups, mainly regarding salivary proteins involved in taste sensitivity and metabolism, point to the potential of using saliva in the study of obesity development.
Type: article
Appears in Collections:MED - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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