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Title: Novel bisphosphonates derived from 1H-indazole, 1H-pyrazolo[3,4-b]pyridine and 1H-pyrazolo[3,4-b]quinoline
Authors: Teixeira, António P. S.
Teixeira, Fátima C.
Lucas, Carla
Curto, M. João M.
Duarte, M. Teresa
André, Vânia
Editors: Gates, Derek P.
Keywords: Bisphosphonate
Microwave-assisted reaction
Issue Date: Jan-2016
Publisher: Wiley
Citation: Teixeira, F. C., Lucas, C., Curto, M. J. M., Teixeira, A. P. S., Duarte, M. T. and André, V. (2016), Novel Bisphosphonates Derived from 1H-Indazole, 1H-Pyrazolo[3,4-b]Pyridine, and 1H-Pyrazolo[3,4-b]Quinoline. Heteroatom Chem., 27: 3–11. doi: 10.1002/hc.21282
Abstract: Novel tetraethyl ethylene-1,1-bisphosphonate esters derived from 1H-indazole, 1H-pyrazolo[3,4-b]pyridine, and 1H-yrazolo[3,4- b]quinoline were synthesized by a Michael addition reaction of tetraethyl ethylidene-1,1-bisphosphonate with the corresponding heterocycle, using conventional heating and microwave-assisted methods. The microwave-assisted method provides shorter reaction times and better yields. The hydrolysis of bisphosphonates afforded the corresponding bisphosphonic acids or salt, using concentrated hydrochloric acid or TMSBr/collidine, respectively. All new compounds were fully characterized, and their structures were assigned using 1H, 31P, and 13C NMR and IR spectroscopies and mass spectrometry. The molecular structure of compound 6 was confirmed by X-ray diffraction studies.
Type: article
Appears in Collections:QUI - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
CQE - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica

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