Please use this identifier to cite or link to this item: http://hdl.handle.net/10174/17112

Title: Biomarkers and toxicological evaluation of Lavandula spp. essential oils
Authors: Arantes, Silvia
Candeias, M. Fátima
Piçarra, Andreia
Lopes, Orlando
Lima, Mónica
Pereira, Marizia
Cruz-Morais, Júlio
Martins, M. Rosário
Editors: Cabrita, António M. S.
Keywords: Lavandula luisieri
Lavandula viridis
essential oil
chemical composition
toxicological evaluation
biochemical biomarkers
Issue Date: Jun-2015
Publisher: Portuguese Experimental Pathology Association
Citation: Arantes S., Candeias M. F., Piçarra A., Lopes O., Lima M., Pereira M., Cruz-Morais J., Martins M. R. (2015) Biomarkers and toxicological evaluation of Lavandula spp. essential oils. Experimental Pathology and Health Sciences: Research, Clinics, Teaching and Society, Journal of the Portuguese Experimental Pathology Association, 7 (1) 46-47.
Abstract: Lavenders belong to the family Labiatae and are one of the most popular aromatic plants widely used in food industry, perfumery and pharmaceutical preparations. Their oils are traditionally believed to be antibacterial, antifungal, carminative, sedative, antidepressive, disinfectant, and effective for burns and insect bites [1]. Previous studies have shown that the essentials oils of Lavandula stoechas subsp. luisieri Rozeira (L. luisieri) and Lavandula viridis L’Hér have a broad-spectrum antimicrobial activity [2]. In present work we have developed a set of studies in vivo, using animal model, in order to evaluate the toxicological proprieties of essential oils (EOs) of two aromatic plants endemic of south of Portugal, namely L. luisieri from Alentejo and L. viridis from Algarve. EOs were obtained from aerial part of plants by hydrodistillation and chemical composition was evaluated by GC-FID. Acute toxicity (LD50) was determined in Swiss mice according to Up-and-Down OECD procedure [3] and oral toxicity assays were performed based on hippocratic screening during 14 days [4], as required by the Direção Geral de Veterinária and FELASA. Histological analyses of the liver and kidney, as well as quantification of biomarkers: aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma glutamyltransferase (γ-GT), creatinine and urea were performed.
URI: http://hdl.handle.net/10174/17112
ISSN: 1646-8422
Type: article
Appears in Collections:ICAAM - Publicações - Artigos em Revistas Nacionais Com Arbitragem Científica

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