Please use this identifier to cite or link to this item:
|Title: ||Nonlinear control of HIV-1 infection with a singular perturbation model|
|Authors: ||Barão, Miguel|
Feedback linearizing control
|Issue Date: ||25-Jul-2007|
|Abstract: ||Using a singular perturbation approximation, a nonlinear state-space model of HIV-1 infection, having as state variables the number of healthy and infected CD4+T cells and the number of virion particles, is simplified and used to design a control law. The control law comprises an inner block that performs feedback linearizing of the virus dynamics and an outer block implementing an LQ regulator that drives the number of virion particles to a number below the specification. A sensitivity analysis of the resulting law is performed with respect to the model parameter to the infection rate, showing that the controlled system remains stable in the presence of significant changes of this parameter with respect to the nominal value.|
|Appears in Collections:||INF - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.