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Title: Antioxidant and Antimicrobial Activities of Arylamide-Acetals derivates: Potential Drugs for Neurodegenerative Diseases
Authors: ARANTES, Sílvia
MARQUES, Carolina
PEIXOTO, Daniela
MARTINS, M. Rosário
BURKE, Anthony
Editors: Oliveira, P.
Ambrósio, F.
Laranjinha, J.
Oliveira, T.
Serafim, T.
Sardão, V.
Keywords: Antioxidant activity
Antimicrobial activity
Arylamide-Acetals derivates
Neurodegenerative Diseases
Issue Date: Dec-2014
Publisher: CNCBUC Editions
Citation: Arantes S., Silva M., Marques C., Peixoto D.A., Martins M.R., Burke A.J., Caldeira A.T. (2014) Antioxidant and Antimicrobial Activities of Arylamide-Acetals derivates: Potential Drugs for Neurodegenerative Diseases. Proceedings of the XVIII Congress of the Portuguese Biochemical Society, (Oliveira P., Ambrósio F., Vega-Naredo I., Laranjinha J., Oliveira T., Serafim T., Sardão V. Eds) CNCBUC Editions, Coimbra, pp- 68.
Abstract: Antioxidants behave as major defense agents against reactive oxygen species (ROS) which are prominent in many serious illnesses, including neurodegenerative diseases such as: Alzheimer’s and Parkinson’s diseases [1]. It is thought that some of the symptoms are due to the imbalance between pro-oxidant and antioxidant homeostasis. Antioxidant defense mechanisms are responsible for the removal of O2, scavenging of reactive oxygen species or inhibition of reactive oxygen species formation [2]. Therefore the discovery of small molecules with antioxidant properties is important in the fight against neurodegenerative diseases and microbial infections [2]. In the present study a small library composed by diazepine and quinolinone derivatives and their precursors (arylamide-acetals) were screened for their antioxidant and antimicrobial properties. Antioxidant activities were evaluated either by free radical DPPH method and -carotene/linoleic acid system. The antimicrobial activities were screened against Gram -positive and Gram- negative pathogenic bacteria by disc diffusion assay, and the minimal inhibitory concentration (MIC) was determined for sensitive strains
Type: article
Appears in Collections:CQE - Artigos em Livros de Actas/Proceedings
MED - Artigos em Livros de Actas/Proceedings

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