http://hdl.handle.net/10174/707 2026-04-07T12:39:04Z http://hdl.handle.net/10174/37423 Title: Prostate cancer. Authors: Faustino-Rocha, Ana; Oliveira, Paula A. Editors: Faustino-Rocha, Ana I; Oliveira, PA Abstract: The prostate is the largest accessory gland of the male reproductive tract. Together with seminal vesicles and bulbourethral glands, the prostate is responsible for the production of an alkaline fluid that forms part of the seminal fluid. The prostates of men over 40 years of age are commonly affected by several pathologies, such as benign prostate hyperplasia and cancer. Prostate cancer is one of the most frequently occurring cancers among men population worldwide. According to the World Health Organization (WHO), in the year 2018, prostate cancer affected approximately 1.28 million men and was responsible for the death of 358,989 of them. Prostate cancer development is associated with several risk factors, such as older age, black ethnicity, a family history of disease, an increased body mass index and obesity. In this way, the risk of prostate cancer development may be reduced through the consumption of a healthy diet full of fruits and vegetables, practice of physical exercise and maintenance of a healthy weight.Despite several approaches being available for prostate cancer treatment, the number of prostate cancer deaths is continuously increasing, which emphasizes the need to search for new methods for precocious diagnosis and more effective treatment. Animal models, including rodents, have greatly contributed to the study of biopathology and the prevention and treatment of prostate cancer.This Special Issue presents original research works, case reports and reviews concerning the diagnosis, treatment and prognosis of prostate cancer, highlighting new advances in this field. 2023-01-01T00:00:00Z http://hdl.handle.net/10174/37288 Title: Addressing new therapeutic strategies using models Authors: Faustino-Rocha, Ana; Oliveira, Paula A Abstract: A disease model displays pathological processes observed in human or animal diseases. The models are fundamental tools in biomedical research, and they are invaluable for providing new insights into mechanisms underlying organ function, establishing the pathophysiology of a disease, and testing potential therapeutic approaches.Models have been long used to study several diseases, including cardiovascular, oncologic, metabolic, infectious, and neurological diseases, among others. Animals or cells displaying pathological processes observed in human or animal diseases have been used as models. Moreover, mathematical models are also of great importance to disease modeling. Animal models offer the unique opportunity to investigate the function of genes and pathways and the in vivo effects of drugs, bridging the gap between basic science and the treatment of diseases. The selection of a suitable model system is a crucial step in research design. For disease modeling to be meaningful, a relevant cellular or genetic phenotype must be observed. Without the use of models, both research and clinical practice worldwide would be vastly different today.This Special Issue aimed to publish original research works or reviews with models of disease, highlighting their importance to search for new therapeutic strategies. 2023-01-01T00:00:00Z http://hdl.handle.net/10174/37287 Title: Prostate cancer Authors: Faustino-Rocha, AI; Oliveira, PA Editors: Faustino-Rocha, AI; Oliveira, PA Abstract: The prostate is the largest accessory gland of the male reproductive tract. Together with seminal vesicles and bulbourethral glands, the prostate is responsible for the production of an alkaline fluid that forms part of the seminal fluid. The prostate of men over 40 years of age is commonly affected by several pathologies, such as benign prostate hyperplasia and cancer. Prostate cancer is one of the most frequent cancers among the male population worldwide. According to the World Health Organization (WHO), in the year 2020, prostate cancer affected approximately 1.41 million men and was responsible for the death of 375,304 of them. Prostate cancer development is associated with several risk factors including older age, black ethnicity, a family history of the disease, an increased body mass index, and obesity. The risk of prostate cancer development may be reduced through the consumption of a healthy diet full of fruits and vegetables, practice of physical exercise, and maintenance of a healthy weight. Despite several approaches being available for prostate cancer treatment, the number of prostate cancer deaths is continuously increasing, which emphasizes the need to search for new methods for precocious diagnosis and more effective treatment. Animal models including rodents have greatly contributed to the study of biopathology and the prevention and treatment of prostate cancer. This Special Issue entitled “Prostate Cancer II” aims to publish original research works and reviews concerning the diagnosis, treatment, and prognosis of prostate cancer, highlighting new advances in this field. 2023-01-01T00:00:00Z http://hdl.handle.net/10174/37281 Title: Addressing new therapeutic strategies using models Authors: Faustino-Rocha, Ana I; Oliveira, Paula A Editors: Faustino-Rocha, Ana I; Oliveira, PA Abstract: A disease model displays pathological processes observed in human or animal diseases. The models are fundamental tools in biomedical research, and they are invaluable for providing new insights into mechanisms underlying organ function, to establish the pathophysiology of a disease, and to test potential therapeutic approaches. Models have been long used to study several diseases, including cardiovascular, oncologic, metabolic, infectious, and neurological diseases, among others. Animals or cells displaying pathological processes observed in human or animal diseases have been used as models. Moreover, mathematical models are also of great importance to disease modeling. Animal models offer the unique opportunity to investigate the function of genes and pathways and the in vivo effects of drugs, bridging the gap between basic science and the treatment of diseases. The selection of a suitable model system is a crucial step in research design. For disease modeling to be meaningful, a relevant cellular or genetic phenotype must be observed. Without the use of models, both research and clinical practice worldwide would be vastly different today. This Special Issue aims to publish original research works or reviews with models of disease, highlighting their importance to search for new therapeutic strategies. 2023-01-01T00:00:00Z