Please use this identifier to cite or link to this item:
http://hdl.handle.net/10174/7172
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| Title: | Expeditious and novel synthesis of alpha-hydroxyesters via rhodium-NHC catalyzed arylation of ethyl glyoxalate |
| Authors: | Burke, Anthony
Marques, Carolina |
| Keywords: | Catálise
alfa-Hidroxiester |
| Issue Date: | 1-Sep-2012 |
| Publisher: | PERGAMON-ELSEVIER SCIENCE LTD |
| Abstract: | The rhodium-NHC catalyzed arylation reaction of ethyl glyoxalate with aryl and alkyl boronic acids provides an efficient method for the synthesis of alpha-hydroxyesters. A wide range of alpha-hydroxyesters (up to 12) were prepared in good to excellent yields. KO'Bu was the base of choice, along with tert-amyl alcohol as the solvent. As far as we are aware, this is the first report of this catalytic arylation, using rhodium-NHC catalysts with this specific substrate type |
| URI: | http://hdl.handle.net/10174/7172 |
| ISSN: | 0040-4020 |
| Type: | article |
| Appears in Collections: | CQE - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica
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CQE - Centro de Química de Évora /
CQE - Publicações - Artigos em Revistas Internacionais Com Arbitragem Científica /
